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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
19.7
Human Site:
Y938
Identified Species:
30.95
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
Y938
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
Chimpanzee
Pan troglodytes
XP_514546
950
108522
Y938
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
Y949
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
Dog
Lupus familis
XP_534324
950
108331
Y938
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
K938
G
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
Rat
Rattus norvegicus
NP_001102066
561
63850
P550
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
S939
Y
G
S
G
R
N
Y
S
L
P
P
P
S
G
R
Chicken
Gallus gallus
Q5ZIP4
949
108524
Y937
A
Y
G
P
G
R
P
Y
L
L
P
P
P
S
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
G897
N
N
Y
Q
Q
Q
G
G
S
R
Q
Q
N
Q
N
Honey Bee
Apis mellifera
XP_392371
860
99367
H848
P
Q
T
L
Y
P
Q
H
H
G
K
S
M
Y
I
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
P959
P
P
G
Y
Q
R
P
P
Y
R
G
G
G
G
G
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
Y1062
G
N
Q
G
G
G
G
Y
P
K
P
P
G
H
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
H1009
R
G
R
G
S
H
H
H
H
D
Q
G
G
N
P
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
Y989
G
Q
Y
S
G
N
S
Y
S
R
N
N
K
Q
S
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
G1059
D
N
R
G
G
Y
R
G
G
G
Y
R
G
G
G
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
100
100
100
N.A.
13.3
13.3
N.A.
20
60
N.A.
N.A.
N.A.
0
0
20
33.3
P-Site Similarity:
100
100
100
100
N.A.
20
20
N.A.
20
60
N.A.
N.A.
N.A.
13.3
13.3
20
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
20
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% D
% Glu:
0
0
7
27
7
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
20
14
14
34
54
14
14
14
7
14
7
14
27
27
47
% G
% His:
0
0
0
0
0
7
7
14
14
0
0
0
0
7
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
0
0
0
7
27
7
0
7
7
0
7
0
0
% K
% Leu:
0
0
0
7
0
0
0
0
20
34
7
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
7
20
0
0
0
14
0
0
0
0
7
7
7
7
7
% N
% Pro:
20
34
7
7
0
7
14
14
34
20
54
60
40
7
7
% P
% Gln:
0
14
7
7
14
7
7
0
0
0
14
7
0
14
0
% Q
% Arg:
7
7
40
7
14
40
14
0
0
20
0
7
0
0
14
% R
% Ser:
0
0
7
7
7
0
7
7
14
0
0
7
14
34
20
% S
% Thr:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
34
14
14
7
7
7
14
47
14
0
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _